February 21st update

Nancy had meetings and scans at the Doctor’s yesterday. She has round two of this Thursday with more meetings and scans. Monday starts the actual trial. Here is a paragraph given to us to explain more about this new med-under-trial:

Indibulin is a microtubule inhibitor. Microtubules are important for maintaining cell structure and allowing for cancer cells to divide and grow. A microtubule inhibitor would reduce this activity. Indibulin is similar to taxanes and vinca alkaloid chemotherapeutics. Indibulin is a synthetic small-molecule chemical entity that binds to tubulin and inhibits cell growth during mitosis. Indibulin does not interact with neuronal tubulins, thus less neurotoxicity (such as neuropathy). (I had help from our trial nurse on this paragraph….chuckle).

Nancy will be one of 3 people in the US on 200mg dosage. The med comes in pill form, and is taken for 5 days, then off 9 days. Monday and Tuesday are basically at the Doctor’s office getting first treatments and then blood draws and observation almost every hour. She also has another visit next Friday. Then it appears to be just Monday meetings and blood draws for the next few weeks.

Our hope is this works really well for Nancy and for many others in the future. Thanks for all your thoughts and prayers.